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Cytochrome P450 3A4 Interaction The concomitant use of Hydrocodone Bitartrate and Acetaminophen Tablets with all cytochrome P450 3A4 inhibitors may result in an increase in Hydrocodone Bitartrate and Acetaminophen Tablets plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression

Healthy Volunteers and Clinical Trials A healthy volunteer is considered someone without any significant health issues and is in good overall health

doi: 10.1038/s41568-019-0187-8 30 SchrevensS.Van ZeebroeckG.RiedelbergerM.TournuH.KuchlerK.Van DijckP