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www.nejm.org/doi/full/ Accessed 15 Jan 2022 Doustimotlagh AH, Eftekhari M (2021) Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin

[42] [43] Half-life is determined by clearance (CL) and volume of distribution (V D ) and the relationship is described by the following equation: In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed