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This has been attributed to increased mechanical fragility (iron deficient RBC are more rigid and more likely to fragment as they traverse through small capillaries under high shear), however oxidative injury to red blood cells is likely contributing to keratocyte formation (Yoo et al 2009) (given that antioxidant enzymes in red blood cells, such as glutathione peroxidase, contain iron)

Homocysteine levels can be high for a number of reasons:[ref][ref] Insufficient folate and B12 (exacerbated by variants in MTHFR, MTR see genotype report below) Not enough B6 (CBS pathway, B6 see genotype report) More methionine than the body can handle Renal insufficiency (kidney disease) or alcoholism Genetic mutations in the CBS gene can cause rare cases of hyperhomocysteinemia

Similar mutation spectra have been obtained TABLE 3-14 Mutation Spectra Indicative of Environmental Exposures and DNA Damage TABLE 3-15 VHL Mutations in Sporadic Renal Cell Carcinomas from cells and animals treated with alkylating agents, such as nitrosamines found in tobacco smoke and potent human and animal renal carcinogens

Hyaluronic Acid (Multi-weight): Provides multi-layered hydration and maintains skin elasticity