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In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo

Tirzepatide has received approval for use in patients with T2D following several phase 3 studies testing and demonstrating its marked anti-hyperglycemic efficacy and positive actions on multiple cardiovascular risk factors, associated with an excellent safety profile [2, 3]

Beyond glycemic control, insulin promotes podocyte autophagy through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway, thereby mitigating high glucose-induced apoptosis and safeguarding cytoskeletal proteins such as nephrin, which in turn diminishes macrophage recognition of damaged podocytes (91) ( Figure 3 )

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