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Heated tobacco products generate a nicotine-containing aerosol by heating tobacco to temperatures sufficient to release nicotine from the tobacco, but low enough to prevent the tobacco from burning

Ironically, whenever Diana had a boyfriend, often in the trunk or the boot of her car, Margaret would be there behind the curtains watching."

[18] It is characterised by an imbalance between vasodilatory and vasoconstrictive substances originating from the endothelium, anticoagulant and procoagulant mechanisms, growth factors and growth inhibitors

1 Similar to combustible cigarette smoking, e-cigarette use could have some negative effects on the oral mucosa and may impair immune defense, increasing susceptibility to infections