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Many commercial preparations contain additional ingredients such as: Sorbitol or mannitol sugar alcohols used as sweeteners in some tablets that can cause osmotic diarrhoea when consumed in larger quantities, though the amounts in typical supplements are usually too small to cause symptoms alone [13] [14] Binding agents and fillers including lactose, which may cause symptoms in people with lactose intolerance, though tablet quantities are typically small Other additives various excipients that some individuals may be sensitive to The dose and frequency of supplementation may also influence tolerability

Alongside these pathways it influences growth-factor signalling, collagen synthesis and fibroblast activity, the building blocks of soft-tissue repair

Penagini, F

patients should use backup or non-oral contraception for 4 weeks after each dose change