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J Endocrinol Invest 46(1):1526 Melo S, Guedes J, Mendes S (2022) Theory of cumulative disadvantage/advantage

Our hypothesis is that deficient eating habits, autoimmune regulator gene predisposing gene, dysbiosis and molecular mimicry, unfolded proteins and stress in the endoplasmic reticulum, and thymus involution appear to be the main potential factors leading to HT oxidative stress