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doi: 10.1016/j.jprot.2012.05.022 15 GreenbergJ

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Although several antibody-based brain delivery techniques have been developed and evaluated in preclinical and clinical studies, including antibody engineering via chemical modifications 24 , none of them have actually been allowed for the widespread use of the delivery of monoclonal antibodies targeting GBM 25 , due to their low loading capacity which hampered binding affinity and potential immunogenicity 26

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