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Such redox-active disulfides have been shown to be important for normal cellular function, with perturbations postulated to be involved in pathological conditions that are characterized by abnormal/altered redox states, including ageing, cardiovascular disease, some cancers, asthma, rheumatoid arthritis, cystic fibrosis and multiple neurodegenerative diseases (e.g., Alzheimers, Parkinsons, Huntingtons, Creutzfeldt-Jakob disease) 7

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Since then, several multi-metabolite methods have been published, covering these compounds, with some examples of recently applied methods listed in Table 3

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