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Comparison between the 2 studied groups There was a high significant difference in reduction percentages of hemi-MASI score of both right sides of face of two groups ( P = 0.001)

Ebselen is therefore a potent bifunctional pharmacological chaperone for SOD1 that combines properties of the SOD1 chaperone hCCS and the recently licenced antioxidant drug, edaravone

Omics analyses revealed that the mechanism involves inhibiting the TNF-/NF-B signaling pathway, suppressing pro-inflammatory genes, and modulating the arachidonic acid metabolism pathway