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Surface chemistry modifications by altering charge density and hydrophobicity have been reported to ameliorate NP toxicity and enhance the efficacy of NPs in biomedical applications (Mout et al., 2012

Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)

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