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It is estimated that 14% of Alzheimers cases worldwide are related to smoking

But these upsides are a smokescreen (if youll pardon the pun)

The following exclusion criteria for smokers and non-smokers were used: acute physical illness, claustrophobia, history of head injury with skull fracture, presence of metal dentures, history of alcohol or drug abuse or dependence, history of central nervous system diseases or conditions, history of medical conditions with significant effects on the central nervous system, history of mental illness, and family history of psychopathic disorders