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8.2, Pharsight Corporation, California, USA) to calculate the pharmacokinetic parameters for each subject, including the bracketed peak concentration (C max ), the area under the blood concentration time curve (AUC 0t and AUC 0 ), the time to peak (T max ), the elimination half-life (t 1/2 ), and the elimination rate constant ()

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Dass das gleiche Medikament bei Menschen mit der gleichen Krankheit unterschiedlich wirken kann, ist seit langem bekannt