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Under irradiation, IGFBP-3 induces apoptosis and ROS production by activating NF-B signaling and ROS further promote IGFBP-3 mediated signaling activity

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Indeed, a significant accumulation of amyloids in the brain vessels can cause their occlusion, thereby blocking blood flow, supplying the brain with oxygen and glucose (de la Torre and Stefano, 2000), and causing neurodegeneration of neurons and memory impairment (Thal et al., 2008, 2009)

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