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Immediately before the analysis, the tissues were homogenized using a Dounce homogenizer containing ice-cold homogenization buffer (0.1% Triton X-100 and 0.6% sulfosalicylic acid dissolved in 0.1 M potassium phosphate buffer with 5 mM EDTA disodium salt, pH 7.5)

PlexusDx emphasizes how genetic insights into peptide sensitivity, combined with clinical assessment, can support more informed conversations with healthcare providers about treatment suitability and monitoring

For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle

Ferroptosis inducers may synergize with proteasome inhibitors, immunomodulatory drugs, or BCL-2 inhibitors to enhance cytotoxicity and overcome resistance