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From our point of view, therapeutic options must not only be directed to reach a molecular target, which ultimately would represent a fixed picture of the disease, but also to restore physiological global context in terms of nitro-oxidative stress and inflammatory response, just as the antioxidant treatment seems to act

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Study selection and data extraction The titles and abstracts of studies identified by the search strategy were independently screened by two reviewers, and irrelevant studies were excluded

Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II