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Animal studies show that the addition of estrogen alone, or estrogen plus progesterone, can increase the size of fibroids .[ref] In the uterus, estrogen upregulates IFG-1 (insulin-like growth factor 1), EGFR, TGF-beta1

Furthermore, there is debate over the efficacy and reliability of in vivo studies of balneotherapy, such as in vivo studies that provide only short-term effects of balneotherapy with no information on long-term effects

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Analysis of pregnancy outcomes indicated that the home quarantine group had a higher prevalence of GDM A1 than GDM A2, and there was also a tendency for pre-eclampsia incidence to increase