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The deleterious polymorphisms of gene and their impact on function of protein, association and linkage of selected gene polymorphisms of the glutathione S-reductase ( GSR ) with various defects/disorders like Obstructive Heart Defects (OHDs)) and hereditary anaemia in humans is also presented here

483 DOX-induced cardiomyopathy results in myocardial autophagy dysfunction, accumulation of iron in both cell and mitochondria, and elevated levels of ROS, 4-HNE, and MDA

This dual exploitation creates multiple therapeutic opportunities: disrupting cancer cell metabolism, inducing alternative cell death pathways, and modulating the immune microenvironment