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Protects Skin From Oxidative Damage By reducing oxidative stress, glutathione helps defend skin cells against environmental aggressors like pollution and UV exposure, two key drivers of premature ageing

The cell surface annotation rate was calculated using a subset of proteins expected to be exposed on the cell surface, which are annotated in UniProt 55 , Human Protein Atlas 56 and Gene Ontology (GO) cellular component 57,58 terms including cell membrane, cell surface, secreted (secretory granule, synaptic vesicle), endosomes (early, late, recycling, membrane), lysosome, plasma membrane (basal, apical, lateral, external side, raft), extracellular regions (space, matrix, vesicle, exosome), immunological synapse, cilium, intercellular bridge, membrane raft, junctions (adherens, bicellular tight, anchoring, cellcell), presynaptic membrane, early endosome, basement membrane, exocyst, ruffle membrane and focal adhesion (Supplementary Table 4)

However, improvements were noted in other symptoms associated with ME/CFS, such as reduced night-time awakenings, suggesting potential long-term benefits for fatigue management [131]

PCR products were purified using the QIAquick PCR purification kit (Qiagen) and eluted in 30 l of nuclease-free water