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GHK-Cu is a naturally occurring tripeptide composed of three amino acids glycine, histidine and lysine bound to a copper ion (Cu)

Cell 60 , 685696 (2015)

Abbreviations aCSF: Artificial cerebrospinal fluid AD: Alzheimers disease AKI: Acute kidney injury ALS: Amyotrophic lateral sclerosis ANOVA: Analysis of variance ATP: Adenosine triphosphate BDNF: Brain-derived neurotrophic factor BSA: Bovine serum albumin CA1: Cornu ammonis 1 CKD: Chronic kidney disease CS: Conditioned stimulus DAPI: 4,6-Diamidino-2-phenylindole DCFH-DA: Dichloro-dihydrofluorescein diacetate DG: Dentate gyrus dUTP: Deoxyuridine triphosphate ELISA: Enzyme-linked immunosorbent assay FA: Friedreich ataxia FCT: Fear conditioning test FITC: Fluorescein isothiocyanate HRP: Horseradish peroxidase IL-6: Interleukin-6 LPS: Lipopolysaccharide MDA: Malondialdehyde MMP: Mitochondrial membrane potential mPTP: Mitochondrial permeability transition pore MS: Multiple sclerosis mtROS: Mitochondrial reactive oxygen species MWM: Morris water maze NBT: Nitro blue tetrazolium NLRP3: NOD-like receptor family, pyrin domain containing 3 OFT: Open field test PD: Parkinsons disease PMSF: Phenylmethylsulfonyl fluoride PND: Perioperative neurocognitive disorders PSD-95: Postsynaptic density protein 95 PVDF: Polyvinylidene difluoride RIPA: Radioimmunoprecipitation assay ROS: Reactive oxygen species SDSPAGE: Sodium dodecyl sulphatepolyacrylamide gels SE: Standard error SOD: Superoxide dismutase SS-31: Szeto-Schiller-31/elamipretide/MTP-131/Bendavia/RX-31/D-Arg-Dmt-Lys-Phe-NH2 SYN: Synaptophysin TBA: Thiobarbituric acid TLR4: Toll-like receptor 4 TNF-: Tumor necrosis factor TrkB: Tropomyosin receptor kinase B TUNEL: Terminal transferase biotinylated-dUTP nick end labeling US: Unconditioned stimulus WB: Western blotting References Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG, Nomenclature Consensus Working Group

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