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At the same time, radiolabeled sdAbs, such as sdAb#2F8 (developed by our laboratory) have shown rapid clearance, high tumor targeting ratios and possible use as theranostic agents

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Given the ancient origin of the Ca 2+ -based signaling, which evolutionary developed earlier than the mitochondrial apoptotic toolkit whose emergence cannot be dated back to the times earlier than eukaryogenesis and acquisition of an endosymbiotic mitochondrion, it can be assumed that the Ca 2+ toolkit takes over a key role in cell death signaling in terminally differentiated mitochondria-free erythrocytes

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