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Unlike traditional over-the-counter antihistamines that merely block histamine from binding to its receptors (H1 or H2) after it has already been released, curcumin works upstream to prevent the release of histamine in the first place

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Biot C, Bauer H, Schirmer RH, Davioud-Charvet E (2004) 5-substituted tetrazoles as bioisosteres of carboxylic acids