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doi: 10.1016/0304-3940(94)90508-8 38 MogiMHaradaMRiedererPNarabayashiHFujitaKNagatsuT

These observations were further elaborated by McDonald and Phillips, who reported in 1969 that the experimental NMR spectra of many denatured proteins (lysozyme, ribonuclease, pepsin, trypsin, apoferredoxin, apo-flavodoxin, oxytocin, and cytochrome c ) were closely matched by the spectra computed by summing the spectra of the equivalent free amino acids, indicating the random coil-like structure of unfolded forms of globular proteins (McDonald and Phillips, 1969

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