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Cold Spring Harb Perspect Med

Vitamin B12, also known as cobalamin , is an essential water-soluble vitamin that supports several vital functions in the body: Red blood cell production Nervous system health DNA synthesis Energy metabolism Many people with fatigue, brain fog, or poor nutrient absorption are deficient in B12particularly those with gastrointestinal conditions (like IBS or celiac disease), vegans and vegetarians, or individuals taking certain medications like metformin or proton-pump inhibitors

In addition, Pycnogenol was shown to lower glycated hemoglobin by 10% in the Pycnogenol group, a significant effect compared to placebo

6b), with significantly higher binding at this timepoint compared to earlier and later timepoints