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Considering the physiological role of selenoproteins in antioxidation and the detrimental effects of oxidative stress in chondrocytes, aberrant selenium metabolism is likely to disrupt cartilage homeostasis and cause arthropathic diseases via dysregulation of redox homeostasis (Fig

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Perhaps the best evidence for the Ca 2+ sensing function of the N-terminal hand is the finding that mutation of acidic residues within this domain results in constitutively active store-operated entry (Liou et al