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In the future, we plan to include crude and partially adjusted risk estimates in our analyses to fully incorporate all available risk estimates, to model the adjusted covariates in a more comprehensive way by mapping the adjusted covariates across all studies comprehensively and systematically, and to develop methods to evaluate additional forms of potential bias

The data also suggest that young people who use both e-cigarettes and cigarettes may progress toward heavier use of both products over time, instead of switching from e-cigarettes to cigarettes or substituting e-cigarettes for cigarettes