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Chronic venous insufficiency (CVI) is a venous disease that occurs when the circulatory system is unable to move blood to the heart efficiently

Activated microglia inflict damage on oligodendrocytes through the release of pro-inflammatory cytokines such as IL-1, IL-6, TNF-, and interferons, alongside phagocytic activity, and antigen presentation to CD 4+ T cells via MHC class II [270]

The cerebellar cortex appeared to be the most affected, and the cerebral cortex was the least affected

Courage and strength are needed to ask for help, so if you are ready to take this step forward, take a moment to reflect on the work you have already put in by recognizing your struggle