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This seven subject, double-blind, placebo-controlled, within-group study showed that 28-day, twice daily topical application of an aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola , in combination with a hypocaloric diet and walking 150 minutes per week leads to reduced thigh circumference (1.2 vs 0.8 cm), skinfold thickness (3.7 vs 2.0 mm) and fat mass (100.0 g vs 57.3 g), in relation to placebo

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