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Meanwhile, GRh3 prevents NRF2 from entering the nucleus, thereby suppressing SLC7A11, resulting in GSH depletion and the accumulation of iron, ROS, and MDA, ultimately triggering ferroptosis in CRC cells [296]

Quality control concerns regarding standardization, adulteration with undisclosed synthetic compounds, and contamination with heavy metals or microbial pathogens represent persistent challenges in herbal medicine implementation, particularly problematic in CKD populations with compromised immune function and reduced toxin clearance capacity

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In general, the lower DHAR values were observed in the control treatments (0.21 and 0.26 mol min 1 g 1 F.W