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Analysis of the mice' bone marrow cells, precursors of the monocytes, showed upregulation of proinflammatory cathepsin protein family (CatB and CatZ), which was later terminated during bone marrow differentiation to the macrophages

This review systematically examines the mechanisms of metformin in ameliorating PCOS-associated infertility, with particular emphasis on its pleiotropic effects across critical life stagesfrom pubertal development through pregnancy to long-term health outcomes, thereby providing valuable insights into the clinical application of metformin in the treatment of PCOS