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Description

This phenomenon leads to an ATP drainage, a reduction in glutathione, and a decrease in necrotic death-predisposing cells, among the leading causes of inflammation [9]

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They found that SLC7A11 acts not only as a protective shield against oxidative stress, but also as a suit of armour, controlling the cytoskeleton of the cancer cells a structure that helps them become mobile and aggressive

For instance, one report proposed a model in which AIFM2 attenuates survival signaling in response to cytosolic foreign DNA, thereby contributing to apoptotic cell death 37,39