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The dogs are taught to differentiate the smells and alert a handler to the location by barking or making other physical signals with their bodies

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Other investigators reported that mice deficient in MMP ( MMP*/* ) that had a single exposure to the whole smoke of four 2R1 reference cigarettes did not show the same early elevations in lavage neutrophils, desmosine, or hydroxyproline that are seen in mice with normal levels of MMP activity ( MMP*+/*+ ) (Churg et al