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Description

Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model

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The cytochromes involved include CYP2D6, CYP2C19, CYP2C18, the CYP3A family, CYP1A2, CYP2C9, and CYP2B6, with the first two enzymes having a higher affinity for most antidepressants than the rest of the enzymes (Koyama et al., 1997