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In 1977, to work around FDA regulations, some brands using tobacco substitutes were launched in the UK

LOW-COST CHINESE MANUFACTURING HAS LOWERED THE BAR FOR NEW VAPING BRANDS Manufacturers in the Chinese city of Shenzhen allow customers to order tens of thousands of e-cigarettes for as little as $2 each

from questionable sources.[24] In addition to tax evasioncosting states billions in lost tax revenueblack market e-liquid and cigarettes can be extremely unsafe.[25] In 2019, stories about serious pulmonary diseases prompted the FDA to publish a warning about black market THC-containing liquid (the psychoactive compound in marijuana).[26] Reports of illicit products containing dangerous chemicals resulting in serious medical conditions also arose in 2019.[27] Providing vapers with a well-regulated legal market will limit the distribution of illegal products

One recent study found a significant tie between former or current e-cigarette use and the development of respiratory diseases, including COPD, chronic bronchitis, emphysema and asthma, within two years of use