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Wang Y, Huang M, Zhou X, Li H, Ma X, Sun C

Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

More than 62 proteins are involved directly in transcription, nucleotide metabolism, (de)phosphorylation, or (de)ubiquitinylation, which are all essential processes for cell cycle progression [50]

In fact, human recombinant HGF (hHGF) and hHGF gene therapy (Collategene, a hHGF DNA plasmid) have been examined as a treatment option in several intractable diseases, such as amyotrophic lateral sclerosis, hepatic cirrhosis and peripheral arterial disease 11,12