evaluated the association between serum UA levels, cerebrospinal fluid biomarkers of AD, and longitudinal cognitive decline using the Alzheimers Disease Neuroimaging Initiative database ( n = 1064, including 271 healthy subjects, 596 MCI, and 197 AD)

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MacMicking, J., Xie, Q
Arginine has been shown in vitro to improve barrier function in caco-2 cells injured with a commonly used immunomodulatory medication (methotrexate) [139]