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[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

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Castilla-Cortzar I, Gago A, Muoz et al (2015c) Mechanisms underlying testicular damage and dysfunction in mice with partial IGF-1 deficiency and the effectiveness of IGF-1 replacement therapy