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[85] conducted the first descriptive analysis of the characteristics of Adverse Event Reports (AER) documenting the misuse and abuse potential of semaglutide compared to other GLP-1RAs (e.g., albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, and tirzepatide) by analyzing the FDA Adverse Events Reporting System (FAERS) pharmacovigilance data set

The NF-B pathway is activated in inflammatory processes such as endothelial-to-mesenchymal transition in doxorubicin-induced cardiotoxicity and osteosarcoma cell growth, where it downregulates miR-506 to promote JAG1 expression (Xiao et al., 2020), mirroring patterns paradigms observed in GPS-related research

Furthermore, the presence of mutations at mitochondrial or nuclear DNA (mtDNA and nDNA, respectively) levels has been linked to personality disorders, behavioral disturbances, thought alterations, impulsivity, learning impairment, cognitive impairment, and dementia

To view a copy of this licence, visit About this article Cite this article Gunn, A.P., Hilton, J.B.W., Mukherjee, S