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Lors d'une tude analogue sur des souris, on a observ le mme genre d'effets histopathologiques avec la mme dose sans effets observables (23 mg/m 3 , 3 ppm)

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In addition, leptin may impair endothelial function through oxidative stress by increasing the formation of ROS that reduce the bioavailability of NO and upregulate proinflammatory cascades including adhesion and chemotactic pathways in endothelial cells [72,73,74]