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The Mediterranean diet, which includes abundant fruits, vegetables, olive oil and whole grains, is loaded with dietary fiber, polyphenols, and unsaturated fatty acids, which improve beneficial bacteria growth, such as butyrate producers, including Clostridium leptum and Eubacterium rectale , and reduce the growth of pro-inflammatory bacteria such as Firmicutes

27 Notably, polyphenols, a class of plant-based compounds found in foods like fruits, vegetables, spices, and tea, have garnered attention for their potent antioxidative properties

Subsequently, his group kept on the modification of the substituent depended on this skeleton, and got a library of the thiazolidine-2,4-dione derivatives

D., Casati P., Walbot V