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Therefore, hyperhomocysteinemia-induced immunoinflammatory disorders and abnormal immune response may aggravate abnormal immunoinflammatory in PD, leading to more progression of PD severity

Lactylation and glomerular injury Within the glomerular microenvironment under persistent hyperglycaemic conditions, lactylation exhibits cell-typespecific regulatory characteristics, coordinating metabolic reprogramming with epigenetic and signalling events that collectively drive glomerular injury and filtration barrier dysfunction in diabetic nephropathy

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In a recent review, it was pointed out that clinical trials investigating the use of dietary modifications to mitigate the adverse effects associated with normal tissue injuries during radiation therapy involving the pelvis have yielded contradictory results (Segers et al., 2019)