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doi: 10.1073/pnas.0704329104 318 FarahCMichelLYMBalligandJL

The mitral cells showed moderate to strong AR staining, in nuclear and cytoplasmic compartments (Fig

They further modified DMB and developed inhibitors targeting CutC and CutD, the major microbial TMA-generating enzyme pair, and when administered as a single oral dose, significantly decreased plasma TMAO concentrations for up to 3 days and rescued the diet-induced enhancements in platelet reactivity and thrombosis in animal models, without increasing bleeding risk or toxicity (Roberts et al., 2018)