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Conditional recommendations may also be applied when the balance of cost and benefits is ambiguous, key organizational interest holders differ about the acceptability or feasibility of the implementation, or the effects on health equity are unclear

E-cigarette sales tripled between 2012 and 2013 rising from $500 million to over $1.5 billion and are expected to soon exceed the sales of traditional cigarettes, motivating giant tobacco and other non-cigarette companies to market this product

E-liquids are an important part of any vaping system and their composition, together with the characteristics of the device, may have an impact on nicotine delivery 21

"Fall-out" refers to microscopic cellulose acetate fibres that break loose from filters during manufacturing or smoking and are then inhaled directly into the smoker's lungs