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Histological examination The inflamed foci of the different paw of rats have been explored for histopathological features

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However, GSH-S-transferase A4-4 knockdown could augment 4-HNE cytotoxicity, and its overexpression could obviously inhibit 4-HNE-induced death of chondrocytes [84]

Hence in the deficiency of folic acid, methanol metabolism could take the alternate pathway (microsomal pathway).28 Conversion of methanol to formaldehyde (HCHO) in humans is catalyzed primarily by alcohol dehydrogenase 1 (ADH1).29 Alternative pathways of metabolism include catalase-mediated reactions, yielding formaldehyde and hydrogen peroxide.30 Formaldehyde may be the ultimate toxicant from methanol exposure