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Indeed, the combination of CB-839 with ATO or HHT exacerbates mitochondrial oxidation and apoptosis in the cell lines, mouse models, and patients of AML [11]

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[DOI] [PubMed] [Google Scholar] 260.Medved I, Brown MJ, Bjorksten AR, McKenna MJ

Therefore, to identify the role of NF-B and the regulative mechanism between GPX1 and NF-B in SGNs damage induced by peroxynitrite, we measured the NF-B pathway in SGNs after peroxynitrite administration with GPX1 upregulation or deficiency (Figure 8A)