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For example, patients prone to DILI may benefit from lower doses and slower upwards titration to avoid the hepatotoxic effects

doi: 10.1016/j.biopha.2018.10.075, PMID: [DOI] [PubMed] [Google Scholar] Nargesi S., Rezaie S

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On the other hand, the regulatory class primarily comprises of TFs ( AREB, AP2/ERF, NAC, bZIP, MYC , and MYB ), signaling protein kinases mitogen activated protein kinases (MAPK), calcium-dependent protein kinases (CDPK), receptor protein kinases and protein phosphatases (phosphoesterases and phospholipase), which triggers signal transduction and expression of genes during stress responses (Wani et al., 2013)