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Recent studies have found that BRAF/ERK inhibitors can release the feedback inhibition of upstream RTK and RAS signals, and the liberation of RTK and RAS signals can facilitate other signalling pathways, such as the PI3K/AKT/mTORC1 pathway, which improves cell growth and proliferation 181

2014;3:CD005195

Iguchi M, Hiroi M, Kanegae H, Ohmori Y

64 BRIC is characterized by acute onset of recurrent bouts (at least two episodes) of cholestasis that present as jaundice and severe pruritus, with periods of no symptoms for weeks to years, 65 and normal laboratory and histology findings during the intervening periods