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2.3 Key bile acid-sensing receptors modulating the TIME 2.3.1 Farnesoid X receptor: transcriptional control linking metabolism and immunity in the TIME The farnesoid X receptor (FXR, encoded by NR1H4), a nuclear receptor superfamily member, is highly expressed in enterohepatic tissues and various immune cells (e.g., macrophages, DCs, T cells) ( Functionally, FXR-mediated transcription often promotes anti-inflammatory effects and supports immune homeostasis

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Superoxide dismutase is an essential enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen, thereby mitigating oxidative stress in cells