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Additional information Peer review information : Nature Communications thanks Kazuei Igarashi, David Nielsen, and the other anonymous reviewer(s) for their contribution to the peer review of this work

Cytochrome p450 oxidoreductase (POR) affects iron metabolism by removing hydrogen from polyunsaturated fatty acids, or by reducing Fe 3+ to Fe 2+ for electron transfer, to accelerate the circulation between Fe 3+ and Fe 2+ to promote ferroptosis (Zou et al., 2021)

These injections are frequently coupled with the desire to achieve skin-lightening results

This situation is associated with an increased risk of heart disease, such as atherosclerosis, thrombosis and heart disease