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In the subset of 40 efficacy-evaluable, treatment-nave patients, the ORR was 77.5%, with a CR rate of 25.0%

Nevertheless, our results indicate a stimulation of several antioxidant proteins in the cavernosum by the H 2 S donor that may ultimately help to reduce the total ROS burden despite the pro-oxidant conditions

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It has been suggested that AS may be triggered by gut infection with Klebsiella bacteria, but the evidence is circumstantial, based on the observation by some, but not all, investigators of elevated levels of antibodies against Klebsiella pneumoniae in the blood of patients with active disease